AbstractObjective. To investigate leukocyte lipocortin‐1 production in rheumatoid arthritis (RA).Methods. Eight control and 8 RA subjects received 100 mg hydrocortisone intravenously. Leukocyte lipocortin‐1 was measured by enzyme‐linked immunosorbent assay.Results. Hydrocortisone induced significant increases in lipocortin‐1 production by control mononuclear cells (MNC) (P= 0.006 versus baseline) but not by RA MNC (P= 0.44 versus baseline). Peak lipocortin‐1 levels in control MNC were significantly higher than those in RA MNC (P= 0.014).Conclusion. These results indicate that glucocorticoid‐induced MNC lipocortin‐1 production is i
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