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外文期刊>journal of cardiac surgery
>Cardiomyoplasty: Studies on Goat Latissimus Dorsi Blood Flow and Muscle Damage Following Surgical Dissection and Chronic Electrical Stimulation
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Cardiomyoplasty: Studies on Goat Latissimus Dorsi Blood Flow and Muscle Damage Following Surgical Dissection and Chronic Electrical Stimulation
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机译：Cardiomyoplasty: Studies on Goat Latissimus Dorsi Blood Flow and Muscle Damage Following Surgical Dissection and Chronic Electrical Stimulation
AbstractBackground: Dynamic cardiomyoplasty has shown promise as a surgical treatment for congestive heart failure, however, skeletal muscle damage has been reported in the latissimus dorsi muscle flap. Possible etiologies for the muscle damage include surgical dissection of the latissimus dorsi muscle with interruption of collateral blood supply, as well as chronic electrical stimulation of the muscle.Methods: To investigate these possible etiologies, we conducted a series of experiments using the goat model, evaluating blood flow and muscle morphology following surgical dissection and chronic stimulation of the latissimus dorsi muscle. Four different conditions were evaluated: (1) latissimus dorsi muscle that was neither dissected nor chronically stimulated; (2) latissimus dorsi muscle that was stimulated, but not dissected; (3) latissimus dorsi muscle that was surgically dissected, but not chronically stimulated; and (4) latissimus dorsi muscle that was both surgically dissected and chronically stimulated.Conclusion: We concluded that skeletal muscle damage resulted primarily from the surgical dissection, whereby the collateral blood supply to the latissimus dorsi muscle was interrupted and not primarily as a result of chronic electrical stimulation.
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