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>Influence of age and of pre‐treatment with D‐cycloserine on the behavior of ethanol‐treated rats tested in the elevated plus‐maze apparatus
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Influence of age and of pre‐treatment with D‐cycloserine on the behavior of ethanol‐treated rats tested in the elevated plus‐maze apparatus
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机译：Influence of age and of pre‐treatment with D‐cycloserine on the behavior of ethanol‐treated rats tested in the elevated plus‐maze apparatus
AbstractThere is evidence that ethanol is able to influence central functions through the antagonism of the NMDA‐receptor system. It has been shown that this system is also involved in the modulation of anxiety‐related behavior in rats. Recently, we observed gender‐ and age‐related behavioral influences in rats tested on the elevated plus‐maze apparatus The present study was undertaken in order to investigate: (1) the effects of ethanol (0.8, 1.0 or 1.2 g/kg, i.p.) on the behavior of male and female rats tested on the elevated plus‐maze at 2, 3, 4 or 5 months of age; (2) the effect of the pre‐treatment with D‐cycloserine (3.0 or 6.0 mg/kg), an agonist of the glutamate NMDA‐receptor system, 30 min before the ethanol (1.2 g/kg) injections, in rats tested in the elevated plus‐maze at 2 months or 4 months of age. The results demonstrated that ethanol did not affect the time spent and the frequency of entries on the open arms of the elevated plus‐maze in rats tested at 2 months of age, but increased these parameters in older animals. Moreover, the results showed that D‐cycloserine, at doses that did not affect the behavior of control animals, antagonized the increased frequency of entries and time spent on open arms produced by ethanol in rats tested at 4 months of age. Our results suggest an age‐related influence on the anxiolytic action of ethanol in rats tested in the elevated plus‐maze. Moreover, the results suggest that the NMDA‐receptor system can be involved in this effect, and strengthens the evidence for the participation of the NMDA‐receptor sys
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