Bioactive phenolics from Seriphidium stenocephalum

ShafiqN.; RiazN.; AhmedS.AshrafM.EjazS.A.AhmedI.SaleemM.TouseefM.I.TareenR.B.JabbarA.

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Bioactive phenolics from Seriphidium stenocephalum

机译：Bioactive phenolics from Seriphidium stenocephalum

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Chromatographic separation of the ethyl acetate soluble part of the methanolic extract from Seriphidium stenocephalum yielded three new compounds: stenocepflavone (1), stenocepflavan (2), and stenocephol (3), together with cirsimaritin (4), 5,7,5′-trihydroxy-3′,4′,6-trimethoxyflavone (5), 5,6,7,5′-tetrahydroxy-4′-methoxyflavone (6), and axillaroside (7). All isolates were characterized with the help of spectroscopic data including 1D, 2D NMR, and high resolution mass spectrometry and/or in comparison with the related compounds in literature. All compounds were tested for in vitro enzyme inhibitory activities against acetylcholinesterase, butyrylcholinesterase, and lipoxygenase. Compounds 1 and 4-7 exhibited significant activity against all the tested enzymes, whereas compounds 2 and 3 were found inactive.

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《Journal of Asian natural products research》 |2013年第4期|286-293|共8页
作者
ShafiqN.; RiazN.; AhmedS.AshrafM.EjazS.A.AhmedI.SaleemM.TouseefM.I.TareenR.B.JabbarA.;
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作者单位

Department of Chemistry, Baghdad-ul-Jadeed Campus, Islamia University of Bahawalpur, 63100;

Department of Botany, University of Baluchistan, Quetta, Pakistan;

Department of Biochemistry and Biotechnology, Baghdad-ul-Jadeed Campus, Islamia University ofDepartment of Pharmacy, Khawaja Fareed Campus, Islamia University of Bahawalpur, 63100, BahawalpurKarlsruhe Institute of Technology (KIT), DFG-Centre for Functional Nanostructures, Wolfgang Gaede;

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原文格式 PDF
正文语种英语
中图分类药学;
关键词
characterization; enzyme inhibition; methanolic extract; phenolics; secondary metabolites; Seriphidium stenocephalum;

Bioactive phenolics from Seriphidium stenocephalum

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