AbstractContinuous monitoring of blood density (BD) was preformed in 4 stable dialysis patients in 20 sessions using a density meter based on a mechanical oscillator technique. Mean predialysis and postdialysis BDs were 1.0427 ± 0.0031 g/cm3and 1.0502 ± 0.0055 g/cm respectively. For similar predialysis to postdialysis total body water reduction, significant difference in the mean BD increase was found between hypotensive and nonhy‐potensive groups (1.29 ± 0.07, 0.47 ± 0.12, respectively; p<0.001). Eight hypotensive episodes occurred during 6 sessions. The mean value of the blood density changes slope(dBD/dt)during the 5 min preceding a hypotensive episode increased about 2.5 times more than did the mean of the predialysis to postdialysis blood density slope (27.6 ± 2.2 g/cm3min 10‐5, 10.5 ± 0.4 g/cm3min 10‐5respectively; p<0.001) under the condition of a constant ultrafiltration rate of 18.9 ± 0.6 ml/min. Continuous monitoring of blood density allows abrupt change in plasma volume to be identified and seems to have a potential utility to the prevention of symptomatic hypotension episodes in patients receiving
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