首页>
外文期刊>Clinical and experimental allergy :
>Comparison of the levels of the major allergensDer pI andDer pII in standardized extracts of the house dust mite, Dermatophagoides pteronyssinus
【24h】
Comparison of the levels of the major allergensDer pI andDer pII in standardized extracts of the house dust mite, Dermatophagoides pteronyssinus
展开▼
机译：Comparison of the levels of the major allergensDer pI andDer pII in standardized extracts of the house dust mite, Dermatophagoides pteronyssinus
SummaryAllergy to the house dust miteDermatophagoides pteronyssinusis mediated by IgE to the major allergensDer pI andDer pII in the majority of mite‐allergic patients. In recent years, standardized preparations ofD. pteronyssinus, commercially available from several sources, have become widely used for the diagnosis and immunotherapy of mite allergy. As standardization implies uniformity of allergen composition and potency, we directly compared the absolute and relative quantities ofDer pI andDer pII in six different commercial standardized extracts ofD. pteronyssinus. Our findings reveal variability in levels of bothDer pI andDer pII, producing ratios ofDer pI/Der pII ranging from 1.1/1 to 6/1. Although the content of minor allergens in the extracts was not evaluated here, their contribution to the overall reactivity of mite‐allergic patients to the commercial extracts was judged to be minimal. This was demonstrated by showing that plasma depleted of reactivity to bothDer pI andDer pII had virtually no residual IgE directed against extract components. The variation in the proportion ofDer pI andDer pII among differentD. pteronyssinusextracts is likely to influence their biological effectiveness. Patients with reactivity against onlyDer pI orDer pII, who were found to comprise approximately one‐third of the mite‐allergic population, may not respond optimally to extracts containing relatively low levels of the allergen to which they are se
展开▼
