SummaryA simple method is described which enables measurement of anti‐IgE antibodies in free form as well as in immune complexes of IgE and anti‐IgE. Anti‐IgE antibodies were purified from serum of one selected blood donor with highly elevated levels of such auto‐antibodies. These purified anti‐IgE auto‐antibodies inhibited the measurement of myeloma IgE. Purification also revealed that 98 of the subject's serum IgE was masked by anti‐IgE auto‐antibodies. Our data suggest that IgE determinations in sera containing anti‐IgE antibodies might
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