DNA damage-induced cell death: lessons from the central nervous system.

Borges HL; Linden R; Wang JY

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DNA damage-induced cell death: lessons from the central nervous system.

机译：DNA damage-induced cell death: lessons from the central nervous system.

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摘要

DNA damage can, but does not always, induce cell death. While several pathways linking DNA damage signals to mitochondria-dependent and -independent death machineries have been elucidated, the connectivity of these pathways is subject to regulation by multiple other factors that are not well understood. We have proposed two conceptual models to explain the delayed and variable cell death response to DNA damage: integrative surveillance versus autonomous pathways. In this review, we discuss how these two models may explain the in vivo regulation of cell death induced by ionizing radiation (IR) in the developing central nervous system, where the death response is regulated by radiation dose, cell cycle status and neuronal development.

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来源
《Cell research》 |2008年第1期|17-26|共10页
作者
Borges HL; Linden R; Wang JY;
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作者单位

Division of Hematology/Oncology, Moores Cancer Center, Department of Medicine, University of California, San Diego, 3855 Health Sciences, La Jolla, CA 92093-0820, USA.;

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收录信息美国《科学引文索引》(SCI);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类细胞生物学;
关键词
Animals; Apoptosis; Caspases; Cell Death; DNA Damage; DNA Fragmentation; Enzyme Activation; Humans; Models; Biological; Radiation Dosage; Radiation Injuries; Experimental; Radiation; Ionizing; Retina/growth development/radiation effects;

DNA damage-induced cell death: lessons from the central nervous system.

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