Pleuromutilins. Part 1. The identification of novel mutilin 14-carbamates.

Brooks G; Burgess W; Colthurst DHinks JDHunt EPearson MJShea BTakle AKWilson JMWoodnutt G

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Pleuromutilins. Part 1. The identification of novel mutilin 14-carbamates.

机译：Pleuromutilins. Part 1. The identification of novel mutilin 14-carbamates.

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A novel series of mutilin 14-carbamates has been discovered as a result of structure-activity studies on the naturally occurring antibiotic pleuromutilin (1). In particular, the 4-methoxybenzoylcarbamate, SB-222734 (15o) displays potent antibacterial activity against a number of bacterial pathogens which are resistant to currently used agents and shows enhanced metabolic stability when compared to earlier pleuromutilin derivatives. Such derivatives therefore have the potential to provide a new class of antibacterial agents for human therapy which address the threat of bacterial resistance.

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来源
《Bioorganic and medicinal chemistry》 |2001年第5期|1221-1231|共11页
作者
Brooks G; Burgess W; Colthurst DHinks JDHunt EPearson MJShea BTakle AKWilson JMWoodnutt G;
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作者单位

SmithKline Beecham Pharmaceuticals Research and Development, Discovery Chemistry Europe, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK;

harsight.com;

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正文语种英语
中图分类药学;生物化学;
关键词
Antibiotics; Diterpenes; Haemophilus influenzae; Staphylococcus; Biological Factors; 抗生素类; 二萜类; 嗜血菌; 流感; 葡萄球菌属;

Pleuromutilins. Part 1. The identification of novel mutilin 14-carbamates.

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