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>The ERE‐like sequence from the promoter region of the testis specific HSP70‐related gene is not estrogen responsive.
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The ERE‐like sequence from the promoter region of the testis specific HSP70‐related gene is not estrogen responsive.
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机译：The ERE‐like sequence from the promoter region of the testis specific HSP70‐related gene is not estrogen responsive.
AbstractThe 5′flanking region of the hsp70‐related gene which is specifically expressed in rat and mouse spermatocytes contains the GGTCAnnnCGACC sequence closely resembling the palindromic consensus ERE (estrogen responsive element, GGTCAnnnTGACC). We used a transient expression assay to study whether this ERE‐like sequence can transfer estrogen responsiveness either to heterologous or homologous promoters linked to a reporter CAT gene. We found that the GGTCAnnnCGACC sequence either as an isolated element or in its natural sequence context does not respond to hormone stimulation in MCF‐7 and Fe33 cells. This observation points to the importance of the T‐nucleotide in a right half‐palindrome of ERE for ligand‐dependent activation of
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