The pharmacokinetics and dose requirements of disopyramide were evaluated in 10 infants and children during the course of routine therapeutic drug monitoring. Drug clearance was estimated using a Bayesian parameter estimation program and found to range from 0.09‐0.31L/h/kg. Concentrations associated with a satisfactory response were achieved with doses of 15‐20mg/kg/day in most patients, but some required higher doses of 25‐30mg/k
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