Quantification of biological aging in young adults

Belsky Daniel W.; Caspi Avshalom; Houts RenateCohen Harvey J.Corcoran David L.Danese AndreaHarrington HonaLeeIsrael SalomonLevine Morgan E.Schaefer Jonathan D.Sugden KarenWilliams BenYashin Anatoli I.Poulton RichieMoffitt Terrie E.

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Quantification of biological aging in young adults

机译：Quantification of biological aging in young adults

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Antiaging therapies show promise in model organism research. Translation to humans is needed to address the challenges of an aging global population. Interventions to slow human aging will need to be applied to still-young individuals. However, most human aging research examines older adults, many with chronic disease. As a result, little is known about aging in young humans. We studied aging in 954 young humans, the Dunedin Study birth cohort, tracking multiple biomarkers across three time points spanning their third and fourth decades of life. We developed and validated two methods by which aging can be measured in young adults, one cross-sectional and one longitudinal. Our longitudinal measure allows quantification of the pace of coordinated physiological deterioration across multiple organ systems (e.g., pulmonary, periodontal, cardiovascular, renal, hepatic, and immune function). We applied these methods to assess biological aging in young humans who had not yet developed age-related diseases. Young individuals of the same chronological age varied in their "biological aging" (declining integrity of multiple organ systems). Already, before midlife, individuals who were aging more rapidly were less physically able, showed cognitive decline and brain aging, self-reported worse health, and looked older. Measured biological aging in young adults can be used to identify causes of aging and evaluate rejuvenation therapies.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2015年第30期|E4104-E4110|共7页
作者
Belsky Daniel W.; Caspi Avshalom; Houts RenateCohen Harvey J.Corcoran David L.Danese AndreaHarrington HonaLeeIsrael SalomonLevine Morgan E.Schaefer Jonathan D.Sugden KarenWilliams BenYashin Anatoli I.Poulton RichieMoffitt Terrie E.;
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作者单位

Duke Univ, Dept Psychol & Neurosci, Durham, NC 27708 USA;

Duke Univ, Sch Med, Dept Med, Durham, NC 27710 USA;

Duke Univ, Ctr Genom & Computat Biol, Durham, NC 27708 USAKings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Res Ctr, London SE5 8AF, EnglandHebrew Univ Jerusalem, Dept Psychol, IL-91905 Jerusalem, IsraelUniv Calif Los Angeles, David Geffen Sch Med, Gonda Res Ctr, Dept Human Genet, Los Angeles, CA 90095 USADuke Univ, Social Sci Res Inst, Durham, NC 27708 USAUniv Otago, Dept Psychol, Dunedin 9016, New Zealand;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
biological aging; cognitive aging; aging; healthspan; geroscience;

Quantification of biological aging in young adults

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