27 patients with pernicious anaemia, followed for a long period, were consecutively treated with three different vitamin B12preparations, while during intervening period no therapy was given until signs of B12deficiency developed. After vitamin B12treatment, a peak whole blood folate value some 70 higher than the starting value was noted after about 75 d in patients treated with B12injections and after about 165 d in perorally treated patients. During the same time significantly increased whole blood folate/plasma folate ratio was noted. In most of the patients, whole blood folate declined from peak to plateau level in about 150 d and thereafter remained almost unchanged until signs of cobalamin deficiency developed. The mean time from peak to plateau values was significantly longer in “long‐reactors” than in “short‐reactors”. Higher peak and plateau values were noted in patients with neuropathy and mucosal symptoms, as compared to patients with hypers
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