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首页> 外文期刊>島津評論 >Determination of Glucocorticoids in Milk Powder by Ultra High-performance Liquid Chromatography/Tandem Mass Spectrometry
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Determination of Glucocorticoids in Milk Powder by Ultra High-performance Liquid Chromatography/Tandem Mass Spectrometry

机译：Determination of Glucocorticoids in Milk Powder by Ultra High-performance Liquid Chromatography/Tandem Mass Spectrometry

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摘要

A method for determining seven glucocorticoids (prednisone, prednisolone, hydrocortisone, dexamethasone, beclomethasone, methylprednisolone, and fludrocortisone acetate) in milk powder using a Shimadzu LC-30A ultra high-performance liquid chromatograph coupled with an LCMS-8030 triple quadrupole mass spectrometer was established. Rapid separation and detection of glucocorticoids were completed within 2 minutes. Excellent linearity (the correlation coefficients above 0.999) within the concentration range of 0.5～40 μg/L were obtained. In precision experiments performed with mixed standard solutions at 2 μg/L, 10 μg/L and 40 μg/L, the relative standard deviations of the retention time and peak area of 6 successive injections were below 0.6 and 3.9, respectively. Accuracies at 2μg/L, 10 μg/L and 40μg/L ranged between 80.4 and 105.4. The limit of quantitation for prednisone, prednisolone, hydrocortisone, dexamethasone, beclomethasone and methylprednisolone was 0.4 μg/kg, and that for fludrocortisone acetate was 1.0 μg/kg. Those results indicate the method meets the requirements in the China official method "GB/T 21981-2008 Method for determination of hormone residues in animal derived food by liquid chromatography-tandem mass spectrometry".

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