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首页> 外文期刊>neuropsychobiology >Contingent Negative Variation and Reaction Time in Patients with Presenile Idiopathic Cognitive Decline and Presenile Alzheimer-Type Dementia
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Contingent Negative Variation and Reaction Time in Patients with Presenile Idiopathic Cognitive Decline and Presenile Alzheimer-Type Dementia

机译：Contingent Negative Variation and Reaction Time in Patients with Presenile Idiopathic Cognitive Decline and Presenile Alzheimer-Type Dementia

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Up to date 6 patients with initial presenile idiopathic cognitive decline (PICD) and 5 suffering from a presenile Alzheimer-type dementia (PAD) with a mean age of 59.5 were admitted to the trial. The 6 PICD patients were assigned to a double-blind nicergoline/placebo 6-month course with an oral dose of 30 mg twice a day. PAD patients were treated in an open design (nicergoline oral dose 30 mg twice a day) for at least 6 months. Until now only 4 PICD and 3 PAD patients have been treated regularly for 6 months. Two of 4 PICD patients showed a progressive enhancement of contingent negative variation (CNV), shorter reaction time (RT) and an improvement of clinical status. The other 2 PICD patients, on the contrary, showed a progressive mild worsening of CNV-RT and clinical patterns. The double-blind trial is not yet completed. CNV activity, RTs and clinical patterns progressively improved also in 2 PAD patients while in the 3rd they remained nearly unchanged or minimally worse during the 6-month treatment. The positive nicergoline effect on CNV-RT and clinical status noted in our patients appeared similar to that observed by other authors with DHEMT in patients with senile dementia of Alzheimer type. No adverse drug-related reactions were seen.

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