Insulin induces a shift in lipid and primary carbon metabolites in a model of fasting-induced insulin resistance

Olmstead Keedrian I.; La Frano Michael R.; Fahrmann JohannesGrapov DmitryViscarra Jose A.Newman John W.Fiehn OliverCrocker Daniel E.Filipp Fabian V.Ortiz Rudy M.

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Insulin induces a shift in lipid and primary carbon metabolites in a model of fasting-induced insulin resistance

机译：Insulin induces a shift in lipid and primary carbon metabolites in a model of fasting-induced insulin resistance

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Introduction Prolonged fasting in northern elephant seals (NES) is characterized by a reliance on lipid metabolism, conservation of protein, and reduced plasma insulin. During early fasting, glucose infusion previously reduced plasma free fatty acids (FFA); however, during late-fasting, it induced an atypical elevation in FFA despite comparable increases in insulin during both periods suggestive of a dynamic shift in tissue responsiveness to glucose-stimulated insulin secretion.

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《Metabolomics :》 |2017年第5期|art. no. 60-art. no. 60|共16页
作者
Olmstead Keedrian I.; La Frano Michael R.; Fahrmann JohannesGrapov DmitryViscarra Jose A.Newman John W.Fiehn OliverCrocker Daniel E.Filipp Fabian V.Ortiz Rudy M.;
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作者单位

Univ Calif Davis, NIH West Coast Metabol Ctr, Davis, CA 95616 USA;

Univ Calif, Syst Biol & Canc Metab, Program Quantitat Syst Biol, 5200 North Lake Rd, Merced, CA;

Univ Calif, Mol Cell Biol, Sch Nat Sci, 5200 North Lake Rd, Merced, CA 95343 USASonoma State Univ, Biol, Rohnert Pk, CA 94928 USA;

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正文语种英语
中图分类生理学;
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Endocannabinoids; Fatty acids; Lipidomics; Metabolomics; Substrate metabolism;

Insulin induces a shift in lipid and primary carbon metabolites in a model of fasting-induced insulin resistance

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