ANALGESIC, ANTI-INFLAMMATORY AND ANTIULCER ACTIVITY OF NITRIC OXIDE RELEASING ESTER DERIVATIVES OF INDOMETHACIN

NEELAM VASHIST; J. SINGH AND D. P. PATHAK

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ANALGESIC, ANTI-INFLAMMATORY AND ANTIULCER ACTIVITY OF NITRIC OXIDE RELEASING ESTER DERIVATIVES OF INDOMETHACIN

机译：消炎痛一氧化氮释放酯衍生物的镇痛，抗炎和抗炎活性

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Analgesic, antiinflammatory and antiulcer activity of newly synthesized nitric oxide (NO) releasing ester derivatives of indomethacin were evaluated in rats. Synthetic compounds (NB-02, NP-02 and NE-02) 6 mg/kg, po each significantly (P<0.01) increased the tail flick reaction time in rats. Antinociceptive effects of two derivatives (NB-02 and NE-02) were compared to that of the parent compound. Indomethacin derivatives (NB-02, NP-02 and NE-02) exhibited significant (P<0.01) anti-inflammatory activity as observed in carrageenan induced rat paw inflammatory model. The severity of gastric lesion were also significantly (P<0.01) less in animals treated with ester derivatives of indomethacin (NB-02, NP-02 and NE-02) as compared to mo-control.

机译：在大鼠中评估了新合成的吲哚美辛释放一氧化氮（NO）酯衍生物的镇痛，抗炎和抗溃疡活性。合成化合物（NB-02，NP-02和NE-02）的6 mg / kg，口服均显着（P <0.01）延长了大鼠的甩尾反应时间。比较了两种衍生物（NB-02和NE-02）与母体化合物的镇痛效果。如在角叉菜胶诱导的大鼠爪炎模型中观察到的，消炎痛衍生物（NB-02，NP-02和NE-02）具有显着的（P <0.01）抗炎活性。与吲哚美辛的酯衍生物（NB-02，NP-02和NE-02）相比，用吲哚美辛酯衍生物（NB-02，NP-02和NE-02）治疗的动物的胃部病变严重程度也显着降低（P <0.01）。

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《Indian journal of physiology and pharmacology》 |2010年第3期|共7页
作者
NEELAM VASHIST; J. SINGH AND D. P. PATHAK;
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正文语种 eng
中图分类人体生理学;
关键词
analgesia; nitric oxide; indomethacin derivatives;

机译：镇痛;一氧化氮;吲哚美辛衍生物;

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1. ANALGESIC, ANTI-INFLAMMATORY AND ANTIULCER ACTIVITY OF NITRIC OXIDE RELEASING ESTER DERIVATIVES OF INDOMETHACIN [J] . NEELAM VASHIST, J. SINGH AND D. P. PATHAK Indian journal of physiology and pharmacology . 2010,第3期

机译：消炎痛一氧化氮释放酯衍生物的镇痛，抗炎和抗炎活性
2. Design, synthesis, and evaluation of anti-inflammatory, analgesic, ulcerogenicity, and nitric oxide releasing studies of novel indomethacin analogs as non-ulcerogenic derivatives [J] . BhandariS.V., ParikhJ.K., BotharaK.G., Journal of enzyme inhibition and medicinal chemistry. . 2010,第4期

机译：设计，合成和评估新型消炎痛类似物作为非致溃疡性衍生物的消炎，镇痛，促溃疡和释放一氧化氮的研究
3. Design, synthesis, and evaluation of anti-inflammatory, analgesic, ulcerogenicity, and nitric oxide releasing studies of novel indomethacin analogs as non-ulcerogenic derivatives [J] . Journal of enzyme inhibition and medicinal chemistry. . 2010,第4期

机译：设计，合成和评估消炎痛，镇痛剂，致溃疡性和一氧化氮释放作为非致溃疡性衍生物的新型吲哚美辛类似物的研究
4. A NITRIC OXIDE-RELEASING NONSTEROIDAL ANTI-INFLAMMATORY DRUG [C] . T. Dyakonov, N. Ekwuribe, T. Harris, International symposium on controlled release of bioactive materials;Consumer diversified products conference . 2001

机译：释放一氧化氮的非甾体抗炎药
5. Nitric oxide synthase in confined environments: Detection and quantification of nitric oxide released from cells and modified liposomes using a sensitive metal catalyst-PEDOT modified carbon fiber electrode. [D] . Perera, P. A. Reshani H. 2009

机译：密闭环境中的一氧化氮合酶：使用敏感的金属催化剂-PEDOT修饰的碳纤维电极检测和定量从细胞和修饰的脂质体释放的一氧化氮。
6. NOSH-sulindac (AVT-18A) is a novel nitric oxide- and hydrogen sulfide-releasing hybrid that is gastrointestinal safe and has potent anti-inflammatory analgesic antipyretic anti-platelet and anti-cancer properties [O] . Khosrow Kashfi, Mitali Chattopadhyay, Ravinder Kodela 2015

机译：NOSH-舒林酸（AVT-18A）是一种新型的释放一氧化氮和硫化氢的混合物具有胃肠道安全性并具有有效的抗炎镇痛退热抗血小板和抗癌特性
7. Design, synthesis, and evaluation of anti-inflammatory, analgesic, ulcerogenicity, and nitric oxide releasing studies of novel indomethacin analogs as non-ulcerogenic derivatives [O] . Shashikant V. Bhandari, Jignesh K. Parikh, Kailash G. Bothara, 2010

机译：抗炎，镇痛，溃疡性和一氧化氮释放研究的设计，合成和评价，作为非溃疡性衍生物的新型吲哚美嗪类似物

ANALGESIC, ANTI-INFLAMMATORY AND ANTIULCER ACTIVITY OF NITRIC OXIDE RELEASING ESTER DERIVATIVES OF INDOMETHACIN

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