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>Tissue distribution and metabolism ofO‐(4‐methoxyphenylcarbamoyl)‐3‐diethylaminopropiophenone oxime hydrochloride (USVP‐E142) in the rat
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Tissue distribution and metabolism ofO‐(4‐methoxyphenylcarbamoyl)‐3‐diethylaminopropiophenone oxime hydrochloride (USVP‐E142) in the rat
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机译：Tissue distribution and metabolism ofO‐(4‐methoxyphenylcarbamoyl)‐3‐diethylaminopropiophenone oxime hydrochloride (USVP‐E142) in the rat
AbstractThe disposition of 0‐(4‐methoxyphenylcarbamoyl)‐3‐diethylaminopropiophenone oxime‐(carbonyl)‐14C hydrochloride in the rat was studiedin vivoandin vitro.Upon oral administration, radioactivity was detected within 15 min in many tissues, including the brain. The lung and the liver had the highest levels. The first‐order rate constant for the disappearance of14C from the stomach was 8.2 × 10−3min−1for fasted and 5.7 × 10−3min−1for non‐fasted rats. Most of the radioactivity was eliminated in the form of14CO2. The major metabolic pathway appears to be the hydrolysis of the carbamoyl bond followed by decarboxylation of the resultant carbamic acid, leading to the liberation of CO2. Bis(p‐methoxyphenyl)urea and 3‐diethylamino‐4′‐hydroxypropiophenone wer
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