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首页> 外文期刊>neuropsychobiology >Single or Repeated Treatment with Electroconvulsive Shock Increases Number of Serotonin Uptake Binding Sites in the Frontal Cortex
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Single or Repeated Treatment with Electroconvulsive Shock Increases Number of Serotonin Uptake Binding Sites in the Frontal Cortex

机译：Single or Repeated Treatment with Electroconvulsive Shock Increases Number of Serotonin Uptake Binding Sites in the Frontal Cortex

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The effects of a single or repeated treatment with electroconvulsive shock (ECS) or imipramine on the central serotonin (5-HT) uptake binding sites were studied in the rat frontal cortex and hippocampus. The selective 5-HT uptake inhibitor citalopram and clomipramine potently inhibited the binding for 3Hparoxetine (5-HT uptake binding sites) in the frontal cortex. The antidepressant drugs imipramine and desipramine inhibited the binding moderately, but the 5-HT-related agents, 5-HT, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), mianserin and ketanserin inhibited it weakly. A single ECS increased the density of 3Hparoxetine binding sites, but did not alter the affinity, after 1 or 24 h, in the frontal cortex. Repeated treatment with ECS, but not with imipramine, increased the density of 3Hparoxetine binding sites in the same region. The hippocampal 3Hparoxetine binding did not change after any of these treatments. These results suggest that a single treatment with ECS causes a rapid increase in the neuronal 5-HT transporter complex and the increase lasts for 14 days in the frontal cortex.

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