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Metabolomic biomarkers and?novel dietary factors associated with?gestational diabetes in?China

机译：Metabolomic biomarkers and?novel dietary factors associated with?gestational diabetes in?China

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Introduction Gestational diabetes mellitus (GDM) is impaired glucose tolerance first recognised during pregnancy; itsdevelopment is associated with many adverse outcomes. Mechanisms of GDM development are not fully elucidated and fewstudies have used Chinese participants.Objectives The aim of this study was to investigate the maternal metabolome associated with GDM in a Chinese population,and explore the relationship with maternal diet.Methods Ninety-three participants were recruited at 26–28?weeks’ gestation from Chongqing, China. Maternal urine, serum,and hair metabolomes were analysed using gas and liquid chromatography–mass spectrometry. Dietary intake was assessedusing a 96-item food frequency questionnaire.Results Of the 1064 metabolites identified, 73 were significantly different between cases and controls (P<0.05), but only2-aminobutyric acid had both a p- and q-value<0.05. A “snack-based-dietary-pattern” was associated with an increasedlikelihood of GDM (odds ratio 2·1; 95 confidence interval 1.1–3.9). The association remained significant after adjustmentfor calorie intake but not food volume.Conclusion This study provides a comprehensive characterization of the maternal metabolome. The snack-based dietarypattern associated with GDM suggests that timing and frequency of consumption are important factors in the relationshipbetween maternal diet and GDM.

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