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>The effect of varying extents of Fluosol‐DA or normal saline haemodilution on the dose dependent kinetics of phenytoin in the rat
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The effect of varying extents of Fluosol‐DA or normal saline haemodilution on the dose dependent kinetics of phenytoin in the rat
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机译：The effect of varying extents of Fluosol‐DA or normal saline haemodilution on the dose dependent kinetics of phenytoin in the rat
Abstract—Phenytoin kinetics were determined in rats in which the blood was moderately haemodiluted with 20 or 40 mL kg−1of Fluosol‐DA or normal saline. Rats received one of three intravenous phenytoin doses (10, 40, 50 mg kg−1) 0·5, 24, 48, or 72 h after haemodilution and were compared with non‐exchanged controls. Haemodilution with either 20 or 40 mL kg−1of Fluosol or saline had no influence on the dose‐dependent kinetics of phenytoin. Haemodilution with 40 mL kg−1of Fluosol decreased the half‐life of phenytoin's major metabolite, HPPH, after a 50 mg kg−1dose. Neither Fluosol nor saline haemodilution affected the normal delay in bil
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