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首页> 外文期刊>Journal of Korean medical science. >Treat-to-Target Strategy for Asian Patients with Early Rheumatoid Arthritis: Result of a Multicenter Trial in Korea
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Treat-to-Target Strategy for Asian Patients with Early Rheumatoid Arthritis: Result of a Multicenter Trial in Korea

机译:Treat-to-Target Strategy for Asian Patients with Early Rheumatoid Arthritis: Result of a Multicenter Trial in Korea

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摘要

Background To evaluate the therapeutic benefits of the treat-to-target (T2T) strategy for Asian patients with early rheumatoid arthritis (RA) in Korea. Methods In a 1-year, multicenter, open-label strategy trial, 346 patients with early RA were recruited from 20 institutions across Korea and stratified into 2 groups, depending on whether they were recruited by rheumatologists who have adopted the T2T strategy (T2T group) or by rheumatologists who provided usual care (non-T2T group). Data regarding demographics, rheumatoid factor titer, anti-cyclic citrullinated peptide antibody titer, disease activity score of 28 joints (DAS28), and Korean Health Assessment Questionnaire (KHAQ) score were obtained at baseline and after 1 year of treatment. In the T2T group, the prescription for disease-modifying antirheumatic drugs was tailored to the predefined treatment target in each patient, namely remission (DAS28 Results Data were available for 163 T2T patients and 162 non-T2T patients. At the end of the study period, clinical outcomes were better in the T2T group than in the non-T2T group (LDA or remission, 59.5 vs. 35.8; P Conclusion In Asian patients with early RA, T2T improves disease activity and physical function. Setting a pre-defined treatment target in terms of DAS28 is recommended.

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    Department of Internal Medicine, Yonsei University College of Medicine, Seoul;

    Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul;

    Department of Internal Medicine, Hanyang University School of Medicine, SeoulDepartment of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, SeoulDepartment of Internal Medicine, Catholic University of Daegu School of Medicine, DaeguDepartment of Internal Medicine, Korea University Ansan Hospital, Korea University School of Medicine, SeoulDepartment of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University School of Medicine, AnyangDepartment of Internal Medicine, Jeju National University School of Medicine, JejuDepartment of Internal Medicine, Gangneung Asan Hospital, University of Ulsan College of Medicine, GangneungDepartment of Internal Medicine, Yeungnam University College of Medicine, DaeguDepartment of Internal Medicine, Ewha Womans University College of Medicine, SeoulDepartment of Internal Medicine, Konkuk University School of Medicine, SeoulDepartment of Internal Medicine, Chonnam National University Medical School and Hospital, GwangjuDepartment of Internal Medicine, Dong-A University College of Medicine, BusanDepartment of Internal Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, College of Medicine, SeoulDivision of Rheumatology, Department of Internal Medicine, Inha University College of Medicine, IncheonDepartment of Internal Medicine, Chungnam National University College of Medicine, DaejeonDepartment of Rheumatology, Ajou University School of Medicine, SuwonDepartment of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, SeoulDepartment of Internal Medicine, Chonbuk National University, Medical School, Jeonju;

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  • 正文语种 英语
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  • 关键词

    Rheumatoid Arthritis; Treatment Outcome; Treat-to-target;

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