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外文期刊>european journal of neuroscience
>Failure to Induce Long‐term Depression by an Anti‐Correlation Procedure in Area CA1 of the Rat Hippocampal Slice
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Failure to Induce Long‐term Depression by an Anti‐Correlation Procedure in Area CA1 of the Rat Hippocampal Slice
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机译：Failure to Induce Long‐term Depression by an Anti‐Correlation Procedure in Area CA1 of the Rat Hippocampal Slice
AbstractWe have independently in our two laboratories re‐examined the report by Stanton and Sejnowski (Nature,339, 215 – 218, 1989) that single stimuli to a test pathway in area CA1 of the hippocampal slice, when delivered between short bursts of stimuli to a second, convergent pathway, produce an associative long‐term depression (LTD) in the test pathway. While robust associative LTP was observed when stimuli to the two inputs were correlated in time, the anti‐correlation procedure failed to induce LTD; rather, a trend towards potentiation was observed. This result was obtained using both submerged and interface chambers, and in two different strains of rat. A transient depression lasting for a few minutes could usually be elicited by strong tetanic stimulation; this depression was not restricted to activated p
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