Synthesis and comparison of the biological activity of monocyclic phosphonate, difluorophosphonate and phosphate analogs of the natural AChE inhibitor cyclophostin

Martin Benjamin P.; Vasilieva Elena; Dupureur Cynthia M.Spilling Christopher D.

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Synthesis and comparison of the biological activity of monocyclic phosphonate, difluorophosphonate and phosphate analogs of the natural AChE inhibitor cyclophostin

机译：Synthesis and comparison of the biological activity of monocyclic phosphonate, difluorophosphonate and phosphate analogs of the natural AChE inhibitor cyclophostin

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New monocyclic phosphate, phosphonate and difluorophosphonate analogs of the natural AChE inhibitor cyclophostin were synthesized and their activity toward human AChE examined. Surprisingly, the phosphate, phosphonate, and difluorophosphonate analogs all showed diminished activity when compared with the natural product. (C) 2015 Elsevier Ltd. All rights reserved.

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《Bioorganic and medicinal chemistry》 |2015年第24期|7529-7534|共6页
作者
Martin Benjamin P.; Vasilieva Elena; Dupureur Cynthia M.Spilling Christopher D.;
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Univ Missouri, Dept Chem & Biochem, St Louis, MO 63121 USA;

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正文语种英语
中图分类药学;
关键词
Acetyl cholinesterase; Cyclic phosphonate; Cyclic phosphate; Difluorophosphonate; Inhibition;

Synthesis and comparison of the biological activity of monocyclic phosphonate, difluorophosphonate and phosphate analogs of the natural AChE inhibitor cyclophostin

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