...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>journal of applied toxicology >Acute toxicity study of 1,3,3,5,5‐pentaziridino‐1‐thia‐2,4,6‐triaza‐3,5‐diphosphorine‐1‐oxide (a new antitumor agent with an inorganic ring) in mice, rats and dogs
【24h】

Acute toxicity study of 1,3,3,5,5‐pentaziridino‐1‐thia‐2,4,6‐triaza‐3,5‐diphosphorine‐1‐oxide (a new antitumor agent with an inorganic ring) in mice, rats and dogs

机译：Acute toxicity study of 1,3,3,5,5‐pentaziridino‐1‐thia‐2,4,6‐triaza‐3,5‐diphosphorine‐1‐oxide (a new antitumor agent with an inorganic ring) in mice, rats and dogs

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相关主题

摘要

AbstractIn order to study the safety of 1,3,3,5,5‐pentaziridino‐1‐thia‐2,4,6‐triaza‐3,5‐diphosphorme‐1‐oxide(SOAz), a new antitumor agent, acute toxicity studies by intravenous administration were performed in ddY mice, Wistar rats and beagle dogs. The LD50values in rodents were 325 mg kg−1for male mice, 450 mg kg−1for female mice, 100 mg kg−1for male rats and 82 mg kg−1for female rats. In dogs, the LD50values were 12 mg kg−1for males and 18 mg/kg−1for females. The dosed animals showed diarrhoea and decreased movement in the three species, and emaciation and loss of body weight in mice and rats. Dogs also showed signs of pneumonia. Histopathological examination revealed bone marrow suppression, atrophy of lymphoid organs and testes, and damage to the digestive tract mucosa in the three species. The main causes of death from single‐dose administration were bone marrow aplasia and atrophy of lymphoid tissue in all species, together with gastro‐intestinal ulceration in rats and dog

著录项

获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号