SummaryThe migration velocity and morphology of basophilsin vitrowere examined after the addition of anti‐immunoglobulin (anti‐lgE or anti‐IgG). In atopic asthma patients with high serum IgE levels (more than 1000 i.u./ml) basophils showed increased migration velocity and showed pear‐shaped and palmate processes after the addition of anti‐lgE, but on the addition of anti‐IgG, these basophils did not show increased migration velocity or morphological changes. In intractable asthma patients with low serum IgE levels, these changes occurred with anti‐IgG but not with anti‐IgE. Thesein vitrofindings suggest a basophil reactivity to anti‐IgE and anti‐IgG in individual patients and support our previous differentiation of asthma patients according t
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