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首页> 外文期刊>Experimental Animals >Genes for Difference in Eosinophilic Phenotype between MES and BN.MES-Cyibames Rats Are on Chromosomes 9， 5， and1
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Genes for Difference in Eosinophilic Phenotype between MES and BN.MES-Cyibames Rats Are on Chromosomes 9， 5， and1

机译：MES 和 BN 之间嗜酸性粒细胞表型差异的基因。MES-cyibames 大鼠位于 9、5 和 1 号染色体上

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The Matsumoto Eosinophilia Shinshu (MES) rat strain develops hereditary blood eosinophilia due to the mutant Cybames gene. In contrast, BN.MES-Cyibames congenic rats, in which the mutant Cybames gene introduced into the background of the BN strain, have a normal blood eosinophil level despite showing robust proliferation of eosinophils in the bone marrow. However, the congenic rats manifest focal necrosis with eosinophilic infiltration in the liver, a phenotype rarely observed in the original MES ratstrain. To elucidate the genetic basis for the strain differences, (MES x BN.MES-Cyibames)F2 rats were bred, and genetic analyses of phenotypes for eosinophilia were performed. Blood and bone marrow eosinophil levels in the F2 rats showed broad distributions, suggesting that the traits were under the influence of multiple genes. Genetic association studies revealed that BN-derived marker loci on chromosomes 9 and 5 were responsible for the increase in eosinophil level in the bone marrow, decrease in blood eosinophil level, and the induction of focal necrosis with eosinophilic infiltration in the liver. The BN-derived allele of the marker gene on chromosome 1was responsible for the decrease of both bone marrow and blood eosinophil levels. These data suggest the existence of genes characterizing/distinguishing the eosinophilic phenotypes of MES and BN.MES-Cy/?ames on these chromosomes, and form the basis for positional cloning studies of the genes. These studies will advance the understanding of the mechanisms involved in eosinophil mobilization from the bone marrow and recruitment to the organs.
机译：松本嗜酸性粒细胞增多症信州 （MES） 大鼠品系由于突变的 Cybames 基因而发生遗传性血嗜酸性粒细胞增多症。相比之下，BN.MES-Cyibames 同源性大鼠，其中引入 BN 菌株背景的突变 Cybames 基因，尽管骨髓中嗜酸性粒细胞的强烈增殖，但血液嗜酸性粒细胞水平正常。然而，同源性大鼠表现出局灶性坏死，肝脏中嗜酸性粒细胞浸润，这种表型在原始MES大鼠品系中很少观察到。为了阐明菌株差异的遗传基础，（MES x BN.培育MES-Cyibames）F2大鼠，对嗜酸性粒细胞增多表型进行遗传分析。F2大鼠的血液和骨髓嗜酸性粒细胞水平分布较广，表明性状受到多个基因的影响。遗传关联研究表明，9号和5号染色体上BN来源的标志位点是骨髓中嗜酸性粒细胞水平升高、血液嗜酸性粒细胞水平降低以及肝脏中嗜酸性粒细胞浸润引起的局灶性坏死的原因。1号染色体上标记基因的BN衍生等位基因是骨髓和血液嗜酸性粒细胞水平降低的原因。这些数据表明存在表征/区分 MES 和 BN 嗜酸性粒细胞表型的基因。MES-Cy/？ames 在这些染色体上，并构成了基因位置克隆研究的基础。这些研究将促进对嗜酸性粒细胞从骨髓动员和器官募集所涉及的机制的理解。

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