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首页> 外文期刊>journal of cellular physiology >Plasma membrane K+/H+‐ATPase Fromleishmania donovani
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Plasma membrane K+/H+‐ATPase Fromleishmania donovani

机译：Plasma membrane K+/H+‐ATPase Fromleishmania donovani

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AbstractLeishmania donovanihas an activeK+/H+exchange system on the surface membrane. Modulation of external K+concentration resulted in a corresponding change in internal pH (pHi) suggesting a link between proton and potassium transport. Although a Na+/H+antiporter is present on the plasma membrane, its sensitivity to amiloride suggests that it operates independent of K+/H+exchange. Reduction of cellular ATP with NaN3and KCN inhibits K+/H+exchange showing thereby that the process is energy dependent. The K+/H+exchange is sensitive to inhibitors of the gastric K+/H+‐ATPase. It is concluded that the H+‐ATPase previously reported on the plasma membrane ofL. donovaniis in fact a K+/H+‐ATPase. © 1994 wiley‐L

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