• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>glia >Development of radial glia and astrocytes in the spinal cord of the north american opossum (Didelphis virginiana): An immunohistochemical study using anti‐vimentin and anti‐glial fibrillary acidic protein
【24h】

Development of radial glia and astrocytes in the spinal cord of the north american opossum (Didelphis virginiana): An immunohistochemical study using anti‐vimentin and anti‐glial fibrillary acidic protein

机译：Development of radial glia and astrocytes in the spinal cord of the north american opossum (Didelphis virginiana): An immunohistochemical study using anti‐vimentin and anti‐glial fibrillary acidic protein

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相关主题

摘要

AbstractWe have shown previously that rubrospinal axons grow around a lesion of their pathway in developing opossums and that a critical period exists for that plasticity. As a first step toward addressing the possibility that glial maturation and/or the development of an astrocytic response to lesioning contribute to loss of rubrospinal plasticity, we have studied the normal development of radial glia and astrocytes in the spinal cord of the opossum by immunostaining for vimentin (Vim) and glial fibrillary acidic protein (GFAP). Vim‐like immunoreactivity (Vim‐LI) was present in radial glia throughout the spinal cord at birth (12 days after conception), whereas GFAP‐like immunoreactivity (GFAP‐LI) was limited to cells of comparable morphology in the ventral part of the cervical cord. The subsequent appearance of GFAP‐LI followed ventral to dorsal and rostral to caudal gradients and by postnatal day (PD) 15, it was found in radial glia throughout the cord. At the same age, processes immunostained by either antibody had lost their radial orientation in the ventral horn of the cervical cord. The subsequent transformation from radial glia to astrocytes also followed ventral to dorsal and rostral to caudal gradients. By PD30, mature appearing astrocytes were immunostained by both antibodies at thoracic levels of the spinal cord, the levels lesioned in the plasticity experiments referred to above, and by PD41, they were found at all levels of the cord. Since rubral axons are able to grow around a lesion of the thoracic cord until PD26–30, there is a rough temporal correlation between the transition from radial glia to mature appearing astrocytes and the end of the critical period for plasticity. © 1993 Wil

著录项

获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号