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首页> 外文期刊>journal of cellular biochemistry >Cholera toxin potentiates TPA‐induced mitogenesis and c‐fosexpression in BALB/c‐3T3‐derived proadipocytes
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Cholera toxin potentiates TPA‐induced mitogenesis and c‐fosexpression in BALB/c‐3T3‐derived proadipocytes

机译：Cholera toxin potentiates TPA‐induced mitogenesis and c‐fosexpression in BALB/c‐3T3‐derived proadipocytes

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AbstractTreatment of quiescent density‐arrested A31T6 proadipocytes with medium supplemented with either 12‐O‐tetradecanoylphorbol‐13‐acetate (TPA), insulin, or cholera toxin alone did not simulate G0/G1traverse and initiation of DNA synthesis. Combinations of either TPA and cholera toxin or insulin and cholera toxin caused a small stimulation of proliferation. Addition of medium supplemented with TPA and insulin caused a marked stimulation of cell cycle traverse which was significantly potentiated by the coaddition of cholera toxin. The actions of cholera toxin were mimicked by forskolin. Expression of c‐foswas regulated in a manner that reflected the results of the mitogenic experiments. TPA caused a marked induction of expression, while only a small increase in transcript levels was seen after treatment with cholera toxin. Addition of a combination of cholera toxin and TPA caused a synergistic induction of c‐fosexpression. The model system described in this paper allows a detailed analysis of the regulation, by independent second messenger system, of the transcription of a gene in a mitogenically relevant manner. © 1992 W

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