Impact of hypoalphalipoproteinemia on quality of life in Taiwanese women with central obesity

ChenI.-J.; LinW.-C.; LiuC.-Y.SongY.-L.ChiuJ.-P.HsuC.-H.

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Impact of hypoalphalipoproteinemia on quality of life in Taiwanese women with central obesity

机译：Impact of hypoalphalipoproteinemia on quality of life in Taiwanese women with central obesity

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Purpose: To investigate the relationship between health-related quality of life (HRQoL) and different cutoff value of low level of high-density lipoprotein cholesterol (HDL-C) in Taiwanese women with different definition of obesity. Methods: Prospective observational study in women with central obesity was conducted in Taipei City Hospital. A total of 572 women were screened at our clinic, and 227 of them with a body mass index 27 kg/m2 defined by the Department of Health in Taiwan and weight circumference 80 cm were eligible for the study. We defined two groups as group A-low HDL (HDL-C 40 mg/dL) and group B-high HDL (HDL-C 50 mg/dL) according to different definition of hypoalphalipoproteinemia in obese women. Results: Significantly reduced HRQoL score was noted in group A-low HDL compared to group A-high HDL (HDL-C 40 mg/dL), but not between group B-low HDL and group B-high HDL (HDL-C 50 mg/dL). Positively correlation was noted between HDL-C level and physical domain of HRQoL score. HDL-C contributes independently to physical domain of HRQoL score after controlling for other factors. Decreased leptin and adiponectin level were noted in hypoalphalipoproteinemia groups. Conclusion: Taiwanese obese women with hypoalphalipoproteinemia have adverse impact on HRQoL, especially when the HDL-C level is lower than 40 mg/dL. Both hypoalphalipoproteinemia and hypertension accounted for a great variance to lower scores of physical domain of HRQoL with positively correlation with HDL-C level observed. Decreased leptin and adiponectin were also observed in hypoalphalipoproteinemia group, which implied increased cardiovascular risk. HDL-C level may deem as another indicator for HRQoL in women with central obesity.

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《Quality of life research: An international journal of quality of life aspects of treatment, care and rehabilitation》 |2014年第5期|1619-1627|共9页
作者
ChenI.-J.; LinW.-C.; LiuC.-Y.SongY.-L.ChiuJ.-P.HsuC.-H.;
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作者单位

Branch of Linsen and Chinese Medicine, Taipei City Hospital, Taipei, Taiwan, Institute of;

Branch of Linsen and Chinese Medicine, Taipei City Hospital, Taipei, Taiwan;

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原文格式 PDF
正文语种英语
中图分类医药、卫生;
关键词
Central obesity; Hypoalphalipoproteinemia; Obese women; Quality of life;

Impact of hypoalphalipoproteinemia on quality of life in Taiwanese women with central obesity

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