Immuno‐electron microscopical localization of vimentin and glial fibrillary acidic protein in mouse astrocytes and their precursor cells in culture

Ebtesam M. Abd‐El‐Basset; Ijaz Ahmed; Vitauts I. KalninsSergey Fedoroff

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Immuno‐electron microscopical localization of vimentin and glial fibrillary acidic protein in mouse astrocytes and their precursor cells in culture

机译：Immuno‐electron microscopical localization of vimentin and glial fibrillary acidic protein in mouse astrocytes and their precursor cells in culture

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AbstractImmuno‐electron microscopy was used to localize the distribution of vimentin and glial fibrillary acidic protein (GFAP) in mouse astrocytes and their precursor cells in primary cultures. In astroblasts and astrocytes, vimentin and GFAP form intermediate filaments (IF), which are heteropolymers, as previously observed in gliomas. Astrocytes and their precursor cells may have IF composed of GFAP‐vimentin heteropolymer or vimentin alone, but IF composed of GFAP only were not seen. It seems that the formation of IF that are GFAP‐vimentin heteropolymers is a feature of normal astroglia development and that the ratio of GFAP to vimentin in these IF reflects the degree of differentiation and functional state of the cell. © 1992 Wiley‐L

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《glia》 |1992年第2期|149-153|共页
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Ebtesam M. Abd‐El‐Basset; Ijaz Ahmed; Vitauts I. KalninsSergey Fedoroff;
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Astroglia; Intermediate filaments; Astrocyte differentiation; Heteropolymers;

Immuno‐electron microscopical localization of vimentin and glial fibrillary acidic protein in mouse astrocytes and their precursor cells in culture

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