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首页> 外文期刊>american journal of hematology >Serum vitamin B12and transcobalamin levels in early HIV disease
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Serum vitamin B12and transcobalamin levels in early HIV disease

机译：Serum vitamin B12and transcobalamin levels in early HIV disease

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AbstractA cohort of asymptomatic human immunodeficiency virus (HIV) seropositive patients was followed over a 2 1/2‐year period, to establish changes in serum vitamin B12(B12) concentrations. Serum B12, CD4 count, and clinical progression to acquired immunodeficiency syndrome (AIDS) or AIDS‐related complex (ARC) were measured. The unsaturated B12 binding capacities of the transcobalamins were also determined at the start of the study and compared to those from a homosexual HIV seronegative control group.The geometric mean of serum B12in 218 asymptomatic HIV seropositive patients was significantly lower than of a homosexual HIV seronegative control group (P= 0.02) and the unsaturated B12binding capacities of transcobalamins I and II were significantly higher in the asymptomatic patients compared with the same control group (P<0.03,P<0.0001, respectively).Fifty‐nine of the asymptomatic HIV seropositive patients were followed over a 2 1/2‐year period during which most had falling serum B12levels (64). Twelve patients progressed clinically to ARC or AIDS, of which nine had repeat serum B12estimation prior to progression. All nine patients had or developed falling serum B12levels without any evidence of an HIV‐related bowel disorder. All patients progressing had falling CD4 counts.Subnormal serum B12levels are common in HIV disease and occur at an early stage. B12levels fall in most patients with time and may help predict those patients whose disease will progress the most rapidly. © 1994 Wiley

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