AbstractThe influence of repeated aluminium (Al) administration (0.05 or 0.5 mg 100 g−1b.w.t. i.p. 5 times weekly for 12 weeks) on the lysosomal enzymesN‐acetyl‐beta‐D‐glucosaminidase (β‐NAG) and beta‐glucuronidase (β‐Gluc) in serum, liver, spleen and kidneys of adult female rats with intact kidneys, (NR), or following partial nephrectomy (5/6 NX) was investigated. After Al loading, at the high dose only, the β‐NAG in serum and the free β‐NAG in liver, spleen and kidneys increased. Latent β‐NAG levels decreased in all three organs the effect being dose related. Following Al loading no elevation in total enzyme activity was observed, with one exception. Depending on Al doses the spleen of the non‐operated animals, the liver of both groups of animals and the serum showed a decrease in β‐Gluc activity. No effect on β‐Gluc activity was observed in the spleen of 5/6 NX animals or in the kidneys of either group of animals. The results confirm that high doses of Al induce toxic effects and damage the lysosomes in the liver, the spleen and the kidneys. The results indicate that the extent of lysosomal damage correlates with dose and duration of Al loading. Repeated administration of Al also interferes
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