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>Dietary accumulation and sustained hepatic mixed function oxidase enzyme induction by 2,3,4,7,8‐pentachlorodibenzofuran in rainbow trout
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Dietary accumulation and sustained hepatic mixed function oxidase enzyme induction by 2,3,4,7,8‐pentachlorodibenzofuran in rainbow trout
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机译：Dietary accumulation and sustained hepatic mixed function oxidase enzyme induction by 2,3,4,7,8‐pentachlorodibenzofuran in rainbow trout
AbstractAccumulation of and hepatic monooxygenase induction by 2,3,4,7,8‐pentachlorodibenzofuran (PnCDF) were studied in juvenile rainbow trout (Onchorhynchus mykiss) by feeding treated food for 31 d followed by a 180 d depuration period. Efficiency of assimilation was 44 and 41 at exposure concentrations of 9.0 and 0.82 ng g−1PnCDF, respectively. Depuration of PnCDF followed first‐order kinetics with half‐lives (based on toluene extraction of14C‐radiolabel corrected for growth dilution) of 61 and 69 d at the low and high exposure concentrations, respectively. Monooxygenase enzyme induction measured by ethoxyresorufin‐O‐deethylase (EROD) activity in individual trout livers was 84‐ and four‐fold higher after 31 d of exposure to 9.0 and 0.82 ng g−1, respectively, than in livers of unexposed fish. Sustained EROD activity at the high treatment concentrations was observed during the 180 d depuration phase. Ethoxyresorufin‐O‐deethylase activity declined at approximately half the rate of elimination of PnCDF. No significant differences between growth rates of treated and
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