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外文期刊>american journal of hematology
>Variation in the level of fetal hemoglobin in (δβ)°‐thalassemia heterozygotes with different numbers of α‐globin genes
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Variation in the level of fetal hemoglobin in (δβ)°‐thalassemia heterozygotes with different numbers of α‐globin genes
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机译:Variation in the level of fetal hemoglobin in (δβ)°‐thalassemia heterozygotes with different numbers of α‐globin genes
AbstractThe Sicilian type of (αβ)°‐thalassemia characterized by a ˜13 kb deletion, was present in a Turkish boy who is a homozygote and in his heterozygous parents who are first cousins. The father with ˜21 Hb F had five α‐globin genes (αα/ααα) and the mother with ˜10 Hb F had an α‐thal‐2 heterozygosity (αα/‐α). The difference in Hb F level is explained by a decreased formation of α2γ2tetramers in the mother with an α‐chain deficiency while the extra α‐globin gene in the fa
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