...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>american journal of hematology >Rearrangement and expression of MDM2oncogene in chronic lymphocytic leukemia
【24h】

Rearrangement and expression of MDM2oncogene in chronic lymphocytic leukemia

机译：Rearrangement and expression of MDM2oncogene in chronic lymphocytic leukemia

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相关主题

摘要

AbstractSince trisomy 12 is the most common chromosome abnormality found in CLL and MDM2has been mapped to this chromosome, we examined the possible association of MDM2in the pathogenesis of CLL. A rearrangement of the MDM2gene was observed in 4 of 11 peripheral blood mononuclear cells (PBMC) from patients with CLL by Southern biot hybridization. Expression of MDM2was detected in all of the CLL samples examined by Northern blot. However, neither gross amplification nor overexpression of the MDM2gene was found in CLL. The data suggest that MDM2may play a role in the pathogenesis of CLL and may help to explain how abnormalities of chromosome 12 are related to CLL. © 1994 Wiley‐Liss, I

著录项

获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号