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>Immunogenetic analysis of microsomal and non‐microsomal lipoproteins from normal and malignannt mouse tissues for histocompatibility‐2 (H‐2) antigens
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Immunogenetic analysis of microsomal and non‐microsomal lipoproteins from normal and malignannt mouse tissues for histocompatibility‐2 (H‐2) antigens
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机译：Immunogenetic analysis of microsomal and non‐microsomal lipoproteins from normal and malignannt mouse tissues for histocompatibility‐2 (H‐2) antigens
AbstractTheH‐2antigenic properties of lipoprotein fractions from malignant (L‐5178Y leukemia) and normal (spleen, thymus, liver, kidney) mouse tissues have been studied by serological and immunological tests, and the results compared to the previously described activities of these fractions in homograft‐sensitization tests. Although, in general, the relative activities in the different assays parallel each other some notable exceptions were found. The non‐microsomal lipoproteins from leukemic tissue, inactive in homograft‐sensitization tests, did elicitH‐2antibody. Also, the liver microsomal lipoproteins, which are inactive in homograft‐sensitization tests in amounts 400 × the minimal effective doses of spleen preparations, exhibited, inin vitroagglutinin‐inhibition tests, approximately one‐fourth theH‐2activity of the latter. Other findings of note include the high antibody‐eliciting potency of the spleen and leukemia microsomal lipoproteins (15 μg protein was sufficient to initiate primary immunization and 1 μg protein to cause an anamnestic response); and the quantitive identity ofH‐2antigen activity of the microsomal lipoprote
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