...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>journal of cellular physiology >Transient mitochondrial transcript level decay in oxidative stressed chondrocytes
【24h】

Transient mitochondrial transcript level decay in oxidative stressed chondrocytes

机译：Transient mitochondrial transcript level decay in oxidative stressed chondrocytes

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相关主题

摘要

AbstractSteady‐state levels of 12S rRNA and NADH dehydrogenase subunit 4 mRNA (ND4) mitochondrial transcripts were measured on rabbit articular chondrocyte in culture. In pseudosynchronized chondrocytes, changes of mitochondrial RNA levels were observed during the progression of the cells in the cell cycle. Oxidative stress generated by the hypoxanthine‐xanthine oxidase system (HX‐XO) induced a transient decrease in the levels of both ND4 and 12S rRNA. Mitochondrial RNA levels recovered 24 h after the oxidative stress. These RNA level changes were not associated with modifications in the structure or the copy number of the mitochondrial genome. Furthermore, the decrease in the amount of the mitochondrial transcripts observed may be related to a transient inhibition of mitochondrial transcription since the treatment of cells with ethidium bromide (a mitochondrial transcription inhibitor) resulted in the same decrease in 12S rRNA level as HX‐XO treatment alone. © 1994 Wiley

著录项

获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号