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首页> 外文期刊>journal of cellular physiology >Estrogen enhances epidermal growth factor‐induced DNA synthesis in mammary epithelial cells
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Estrogen enhances epidermal growth factor‐induced DNA synthesis in mammary epithelial cells

机译：Estrogen enhances epidermal growth factor‐induced DNA synthesis in mammary epithelial cells

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AbstractEstradiol (E2) priming (1 nM for 48 h) of normal murine mammary gland epithelial cells significantly increased the response of those cells to epidermal growth factor (EGF)‐induced DNA synthesis. The synergism between E2and EGF was evident in two aspects: After serum‐free synchronization for 24 h, more cells entered the S‐phase of the cell cycle after E2priming and when treated with 0.17 nM EGF (13) than did control cells (1.3) or cells treated with EGF (4) or E2(3.5) alone; further, the dose of EGF required to elicit maximal response was reduced an order of magnitude in estrogen‐primed cells (0.17 nM) compared to controls (1.7 mM). Estrogen alone, however, did not increase DNA synthesis in these cells. Ligand binding studies indicate that these effects of estrogen on proliferating mammary epithelial cells may be explained, at least in part, by a 3.7‐fold increase in the number of high affinity EGF‐receptors observed in estrogen primed cells (7,300 receptors per cell) compared to estrogen deprived cells (1,960 receptors/cell). © 1993 Wil

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