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首页> 外文期刊>Brain research >Temporal memory in mature and aged rats is sensitive to choline acetyltransferase inhibition.
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Temporal memory in mature and aged rats is sensitive to choline acetyltransferase inhibition.

机译：成熟和老年大鼠的时间记忆对胆碱乙酰基转移酶抑制敏感。

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摘要

The effects of a potent inhibitor of choline acetyltransferase (ChAT), BW813U, on timing behavior in mature (6-10 months) and aged (26-30 months) male rats were assessed. Twenty rats were trained on a discrete trial 20-s peak-interval (PI) procedure. During baseline (non-drug) training, the time of the maximum response rate (peak time) for mature rats was approximately at the time of scheduled reinforcement, but peak time for aged rats was reliably later. A single administration of BW813U (100 mg/kg, ip) produced a long-lasting increase in peak time for both mature and aged rats that occurred gradually and was synergistic with age. These horizontal shifts in peak time indicate a change in the content of reference memory for the remembered time of reinforcement that is similar for both aging processes and BW813U administration. When a 5-s gap was imposed in the signal, PI-GAP procedure, control rats of both ages summed the signal durations before and after the gap, whereas rats given BW813U showed no retention of the signal duration prior to the gap. This loss of trial-specific temporal information suggests a drug-induced working memory dysfunction. Taken together, these results demonstrate that both working and reference memory for temporal information are sensitive to choline acetyltransferase inhibition in rats.
机译：评估了胆碱乙酰转移酶（ChAT）的有效抑制剂BW813U对成年（6-10个月）和成年（26-30个月）雄性大鼠定时行为的影响。在不连续的20秒峰值间隔（PI）程序中训练了20只大鼠。在基线（非药物）训练期间，成熟大鼠的最大反应率（峰值时间）的时间大约是计划的强化时间，而老年大鼠的峰值时间则可靠地晚了。一次服用BW813U（100 mg / kg，ip）可使成熟和衰老大鼠的峰值时间长期持续增加，并且逐渐出现并与年龄协同作用。峰值时间的这些水平变化表明，记忆的增强时间参考记忆的内容发生了变化，这与时效过程和BW813U管理均相似。当通过PI-GAP程序在信号中施加5 s间隔时，两个年龄的对照大鼠都将间隔前后的信号持续时间相加，而使用BW813U的大鼠在间隔之前未显示信号持续时间。特定于试验的时间信息的丢失表明药物诱发的工作记忆功能障碍。两者合计，这些结果表明，时间信息的工作记忆和参考记忆均对大鼠胆碱乙酰基转移酶抑制敏感。

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