首页>
外文期刊>journal of applied toxicology
>Induction of electrophysiological and morphological changes in sprague‐dawley rats fed tributoxyethyl phosphate
【24h】
Induction of electrophysiological and morphological changes in sprague‐dawley rats fed tributoxyethyl phosphate
展开▼
机译：Induction of electrophysiological and morphological changes in sprague‐dawley rats fed tributoxyethyl phosphate
AbstractThe effects of a widely used trialkyl phosphate (TP), tributoxyethyl phosphate (TBOP), on the peripheral nervous system of Sprague‐Dawley (SD) rats were investigated. Male and female SD rats were administered this chemical by gavage over a period of 18 weeks (low dose: 0.25 ml kg−1; high dose: 0.50 ml kg−1). Electrophysiological changes observed at 18 weeks in all test animals included a significant reduction (P<0.001) in nerve conduction velocity and an important increase (P<0.001) of both relative (RRP) and absolute refractory period (ARP). Light and electron microscopic examination of sciatic nerve from all test animals showed the presence of degenerating myelin sheaths accompanied by axonal swelling. An advanced stage of degeneration was indicated by the presence of lamellated electron dense inclusions in unmyelinated nerve f
展开▼
