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首页> 外文期刊>Acta physiologica >Control of breathing and ventilatory acclimatization to hypoxia in deer mice native to high altitudes
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Control of breathing and ventilatory acclimatization to hypoxia in deer mice native to high altitudes

机译：Control of breathing and ventilatory acclimatization to hypoxia in deer mice native to high altitudes

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Abstract Aim We compared the control of breathing and heart rate by hypoxia between high‐ and low‐altitude populations of Peromyscus mice, to help elucidate the physiological specializations that help high‐altitude natives cope with O 2 limitation. Methods Deer mice ( Peromyscus maniculatus ) native to high altitude and congeneric mice native to low altitude ( Peromyscus leucopus ) were bred in captivity at sea level. The F1 progeny of each population were raised to adulthood and then acclimated to normoxia or hypobaric hypoxia (12 kPa, simulating hypoxia at ~4300 m) for 5 months. Responses to acute hypoxia were then measured during stepwise reductions in inspired O 2 fraction. Results Lowlanders exhibited ventilatory acclimatization to hypoxia ( VAH ), in which hypoxia acclimation enhanced the hypoxic ventilatory response, made breathing pattern more effective (higher tidal volumes and lower breathing frequencies at a given total ventilation), increased arterial O 2 saturation and heart rate during acute hypoxia, augmented respiratory water loss and led to significant growth of the carotid body. In contrast, highlanders did not exhibit VAH – exhibiting a fixed increase in breathing that was similar to hypoxia‐acclimated lowlanders – and they maintained even higher arterial O 2 saturations in hypoxia. However, the carotid bodies of highlanders were not enlarged by hypoxia acclimation and were similar in size to those of normoxic lowlanders. Highlanders also maintained consistently higher heart rates than lowlanders during acute hypoxia. Conclusions Our results suggest that highland deer mice have evolved high rates of alveolar ventilation and respiratory O 2 uptake without the significant enlargement of the carotid bodies that is typical of VAH in lowlanders, possibly to adjust the hypoxic chemoreflex for life in high‐altitude hypoxia.

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