首页> 外文期刊>Veterinary Research: A Journal on Animal Infection >In vivo studies on lysosubtilin. I. Efficacy for prophylaxis and treatment of gastrointestinal disorders in newborn calves.
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In vivo studies on lysosubtilin. I. Efficacy for prophylaxis and treatment of gastrointestinal disorders in newborn calves.

机译:In vivo studies on lysosubtilin. I. Efficacy for prophylaxis and treatment of gastrointestinal disorders in newborn calves.

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This is the first part of a research report on the in vivo properties of lysosubtilin, a broad-spectrum preparation of lytic enzymes from Bacillus subtilis designed for veterinary medicine. This preparation has both antimicrobial properties and thecapacity to compensate for digestive enzyme deficiencies in newborn calves. This study demonstrates its efficacy for both the prophylaxis and treatment of calf gastrointestinal disorders. Dose determination studies involved calves fed with colostrum or later milk, supplemented with 10 g/litre of sodium bicarbonate, which received either a prophylactic dose of lysosubtilin of 2 X 104 U/kg of body weight given twice daily for 10 days beginning with the first feeding (30-45 min after birth) or a therapeutic dose of 2.5 X 104 U/kg of weight given twice daily until recovery. These could be used for the prophylaxis and treatment, respectively, of the disorders mentioned above with an efficacy up to 100. Trials were carried out in 4 former Soviet Union Republics involving more than 16 000 newborn calves. The efficacy of prophylaxis and treatment was 94.4-100 and 95.7-100 respectively, while the efficacy of regular methods was no higher than 82.0 and 91.8, respectively. A positive impact of lysosubtilin on the improvement of digestive tract functioning, development of an animal and its protective functions against disease was also demonstrated. The consequent increases in calves' daily weight gain, abomasal proteolytic capacity as well as in amount of gamma-globulin, lysozyme and bactericidal activities in their blood sera were significant.

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