AbstractThein vivorelease of14CO2 arising from decarbamoylation of l‐naphthyl methyl 14Ccarbamate (carbaryl) injected into male and femalePeriplaneta americanawas measured over the range from 0.2 to 50 nmol carbaryl/g body weight. The amount of14CO2 released was proportional to the dose of 14C‐carbaryl injected and was not significantly different between male and female cockroaches.Carbaryl was found to be more toxic to male (KD100, 12 nmol carbaryl/g) than female (KD100′ 57 nmol carbaryl/g) cockroaches, at any dose which caused knockdown, females showed a greater ability to recover from the toxic syndrome than did males.The 14C‐carbaryl metabolism (decarbamoylation) was temperature dependent and could be partially inhibited by sesamex, tri‐orthocresyl phosphate and anoxia.Secondary effects of carbaryl poisoning were severe dehydration of the animals and in some cases abdominal swelling due to air being gulped into the crop. The amount of dehydration was essentially unaltered by the chemical inhibitors, but was partially reduced by anoxia and cooling. In the most severe cases of dehydration animals lost 18 of their body wate
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