The diagnosis and management of antral gastrin-(G-) cell hyperplasia was a major topic of interest in the 1970s. Following the discovery ofHelicobacter pyloriin the 1980s, little attention was paid to this condition until it was shown thatH. pyloriinfection was associated with hypergastrinaemia and that eradication of the organism returned the gastrin level to normal. Recent reports have examined the relationship betweenH. pyloriand antral G-cell hyperplasia.H. pyloriinfection is present in about 50percnt; of cases of antral G-cell hyperplasia and, importantly, eradication of the organism normalizes not only the gastrin level but also the antral G-cell count. Eradication treatment should be the therapy of choice. It is also of interest thatH. pylori-negative antral G-cell hyperplasia or hyperfunction does exist. The historical aspects, the relationship between antral G-cell hyperplasia andH. pyloriand recent case reports are reviewed.
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