The chronopharmacokinetics of 4′epiadriamycin (Epi) have been studied in ten patients with gynecological malignancies. The drug (45 mg m−2) was administered as a short time (5.0 min) intravenous infusion at 7 a.m. and 7 p.m., in a randomized crossover design. The pharmacokinetics of Epi were evaluated according to the statistical moment the
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