Crystals of 3‐hydroxy‐3‐methylglutaryl coenzyme A (HMG‐CoA) reductase fromPseudomonas mevaloniihave been grown by vapor diffusion in hanging drops at pH 6.7 using ammonium sulfate as the precipitant. Serial dilution seeding and manipulation of glycerol concentration were both used to obtain crystals larger than 1.0 mm. The crystals are cubic, space groupI4132, witha= 229.4 Å. AVmvalue of 2.71 Å3 Da−lindicates 96 molecules per unit cell with two molecules in the asymmetric unit. These crystals diffract to 2.8 Å with conventional X‐ray sources, and beyond 2.4 Å
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