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>Occurrence of TEM, SHV and CTX-M #946; Lactamases in Clinical Isolates of Proteus Species in a Tertiary Care Center
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Occurrence of TEM, SHV and CTX-M #946; Lactamases in Clinical Isolates of Proteus Species in a Tertiary Care Center
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机译：Occurrence of TEM, SHV and CTX-M #946; Lactamases in Clinical Isolates of Proteus Species in a Tertiary Care Center
Background: Extended spectrum beta lactamases (ESBL) are responsiblefor increased resistance to third generation cephalosporins. Proteus species is an importantcause of both community acquired and nosocomial infections. The Proteusspecies is usually susceptible to beta lactam drugs but there is progressive increase inbeta lactam resistance and recently, ESBLs are also fast spreading to this species.Objective: This study was conducted to study ESBL production and occurrence ofTEM, SHV and CTX-M beta lactamases in clinical isolates of Proteus species in atertiary care center.Method: This prospective hospital based study was carried out in Microbiology,Kasturba Medical College, Mangalore over 9 months. All non-duplicate consecutiveProteus isolates were identified and antibiotic susceptibility testing was done. ESBLdetection was done by double disk synergy method and TEM, SHV, CTX-M geneswere detected by PCR.Results: 84 Proteus isolates from urine (29), blood (1), respiratory secretions (2), tissue(20) and exudates (47) were included in the study. 20.2 (17) were ESBL positiveby disk synergy method. CTX-M was present in 6, TEM in 2 and both in 9 isolates.SHV was not present in any isolate.Conclusion: Our findings showed that 20 of clinical isolates of Proteus specieswere ESBL producers. 52 of ESBL positive isolates carried both TEM and CTX-Mgenes followed by CTX-M alone (35) and only 11 had TEM alone. This stresseson the fact that ESBL detection should be done routinely in Proteus isolates and thegenotype surveyed periodically for better management.
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