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>Sea‐blue histiocyte syndrome in bone marrow secondary to total parenteral nutrition including fat‐emulsion sources: a clinicopathologic study of seven cases
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Sea‐blue histiocyte syndrome in bone marrow secondary to total parenteral nutrition including fat‐emulsion sources: a clinicopathologic study of seven cases
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机译：Sea‐blue histiocyte syndrome in bone marrow secondary to total parenteral nutrition including fat‐emulsion sources: a clinicopathologic study of seven cases
Bone marrow examination revealed a lipid‐laden histiocytosis in seven patients undergoing long‐term total parenteral nutrition necessitated by extensive short‐bowel surgical resection. Clinical abnormalities occurred during this treatment which required bone marrow examination. These included hepatosplenomegaly and peripheral blood cytopenia; the median time to the detection of these abnormalities was 64 months. The most striking change within the bone marrow was the presence of many pigment‐laden histiocytes which had the typical morphology of sea‐blue histiocytes seen in the so‐called idiopathic sea‐blue histiocyte syndrome. The occurrence of sea‐blue histiocytosis in the bone marrow in association with long‐term parenteral nutrition for short‐bowel syndrome has not, to our knowledge, been reported previously and should now be considered in the differential diagnosis of bone marrow s
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